Breast Cancer Therapy Using Dual-Specific T Cells

A histone deacetylase inhibitor, panobinostat, enhances chimeric antigen receptor T-cell antitumor effect against pancreatic cancer

AI Ali, M Wang, B Von Scheidt, PM Dominguez, AJ Harrison, DGM Tantalo, J Kang, AJ Oliver, JD Chan, X Du, Y Bai, B Lee, RW Johnstone, PK Darcy, MH Kershaw, CY Slaney

2021-11-15

Purpose: In this article, we describe a combination chimeric antigen receptor (CAR) T-cell therapy that eradicated the majority of..

Enterotoxins can support CAR T cells against solid tumors

B Von Scheidt, M Wang, AJ Oliver, JD Chan, MK Jana, AI Ali, F Clow, JD Fraser, KM Quinn, PK Darcy, MH Kershaw, CY Slaney

2019-12-10

Responses of solid tumors to chimeric antigen receptor (CAR) T cell therapy are often minimal. This is potentially due to a lack o..

Dual PD-1 and CTLA-4 Checkpoint blockade promotes antitumor immune responses through CD4 þ FOXP3 – cell–mediated modulation of CD103 þ dendritic cells

PA Beavis, MA Henderson, L Giuffrida, AJ Davenport, EV Petley, IG House, J Lai, K Sek, N Milenkovski, LB John, S Mardiana, CY Slaney, JA Trapani, S Loi, MH Kershaw, NM Haynes, PK Darcy

2018-09-01

Immunotherapy is widely accepted as a powerful new treatment modality for the treatment of cancer. The most successful form of imm..

Dual-specific chimeric antigen receptor T cells and an indirect vaccine eradicate a variety of large solid tumors in an immunocompetent, self-antigen setting

CY Slaney, B Von Scheidt, AJ Davenport, PA Beavis, JA Westwood, S Mardiana, DC Tscharke, S Ellis, HM Prince, JA Trapani, RW Johnstone, MJ Smyth, MW Teng, A Ali, Z Yu, SA Rosenberg, NP Restifo, P Neeson, PK Darcy, MH Kershaw

2017-05-15

Purpose: While adoptive transfer of T cells bearing a chimeric antigen receptor (CAR) can eliminate substantial burdens of some le..

A multifunctional role for adjuvant anti-4-1BB therapy in augmenting antitumor response by chimeric antigen receptor T cells

S Mardiana, LB John, MA Henderson, CY Slaney, B Von Scheidt, L Giuffrida, AJ Davenport, JA Trapani, PJ Neeson, S Loi, NM Haynes, MH Kershaw, PA Beavis, PK Darcy

2017-03-15

Adoptive immunotherapy utilizing chimeric antigen receptor (CAR) T cells has demonstrated high success rates in hematologic cancer..

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

PA Beavis, MA Henderson, L Giuffrida, JK Mills, K Sek, RS Cross, AJ Davenport, LB John, S Mardiana, CY Slaney, RW Johnstone, JA Trapani, J Stagg, S Loi, L Kats, D Gyorki, MH Kershaw, PK Darcy

2017-03-01

Chimeric antigen receptor (CAR) T cells have been highly successful in treating hematological malignancies, including acute and ch..

An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy

JA Westwood, S Ellis, J Danne, C Johnson, V Oorschot, G Ramm, DC Tscharke, AJ Davenport, JC Whisstock, PK Darcy, MH Kershaw, CY Slaney

2017-01-01

While immunotherapy employing chimeric antigen receptor (CAR) T cells can be effective against a variety of tumor types, little is..

Using agonist anti-4-1BB to enhance CAR T cell responses against cancer

S Mardiana, LB John, PA Beavis, MA Henderson, L Giuffrida, CY Slaney, RS Cross, NM Haynes, JA Trapani, RW Johnstone, MH Kershaw, PK Darcy

2016-08-01